Antidepressant effects of Dietary Supplements Garlic and Black Sesame Extracts in Ovariectomized Rats: Involving possible Estrogenic and Antioxidant Mechanism

Dietary supplements Garlic and Black Sesame consist of phytoestrogens; it has been clinically used for treating mild depressive disorders by possible Estrogenic and Antioxidant mechanism. The purpose of the study was to examine the effect of dietary supplements on depression in ovariectomized (OVX) rat by despair force swimming test and In vivo-lipid peroxidation study. After the treatment of Garlic 250 and 500 mg/kg and Black Sesame 500 mg/kg P.O. for three month in OVX rats, decrease the immobility period which was compare to OVX control group rats (P<0.0001). Oxidative stress is a measure of steady state level of reactive oxygen species (ROS) in the biological system. Treatment of Garlic and Black Sesame can decrease the oxidative stress in OVX rats. In present study lipid peroxidation was measured in terms of TBARS and result indicate to significant increase in blood serum TBARS content in OVX control rats compared with Sham (SH) control rats (P<0.05). However in oral administration of Estradiol Valerate 0.20mg/kg in standard group and treatment groups of Garlic-250mg/kg, Garlic-500 mg/kg and Black Sesame-500 mg/kg reduced the level of TBARS indicating a decrease rate of lipid peroxidation as compare to OVX control rats (P<0.05). Thus present study concludes that dietary supplements Garlic and Black Sesame containing phytoestrogens can be useful for treating menopausal depression in patients.